Modelling Optimal Control of Heavy Alcohol Consumption on the Transmission Dynamics of HIV/AIDS
Corresponding Author(s) : G. Mwanga
Journal of Humanities & Social Science (JHSS),
Vol. 9 No. 2 (2020): SPECIAL ISSUE OF SCIENCE, 2020
Abstract
Unhealthy consumption of alcohol continues to be found everywhere in our
communities leading to behavioural and physiological effects on neuro-cognitive
function. This results into high-risk sexual behaviour mainly due to impaired decisionmaking capacity and impulsivity, a catalyst of HIV infection and ultimately AIDS. This
paper investigates the best control combination for HIV/AIDS pandemic in a
community with alcohol abuse problem. It proposes a compartmental deterministic
model for the transmission dynamics of HIV/AIDS in a community plagued with
alcohol abuse. The paper determines the implementation of optimal control
strategies involving reduction of new HIV cases through the ABC (abstinence, being
faithful, and use of condoms) campaign, treatment of alcohol abusers and prevention
of alcohol relapse using Pontryagin's maximum principle. Numerical simulations are
implemented using the forward-backward sweep method, and the pertinent results
are presented graphically and discussed quantitatively. Based on performance, results
from numerical simulations depict that the best results are obtained when the three
strategies are used simultaneously.
Keywords: ; ; optimal control; ABC strategy; .
Keywords
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- Agusto, F. B. 2009. Application of Optimal Control to the Epidemiology of HIV-Malaria Co-infection.
- Advances in Disease Epidemiology, 2012(81): 141–170.
- Agusto, F. B. & K. O. Okosun. 2010. Optimal Seasonal Biocontrol for Eichhornia Crassipes. International
- Journal of Biomathematics, 3(3): 383–397. https://doi.org/ 10.1142/ S1793 5245 10001021
- Beaglehole, R., R. Bonita, R. Horton, C. Adams, G. Alleyne, P. Asaria, …, … J. Watt. 2011. Priority
- Actions for the Non-communicable Disease Crisis. The Lancet, 377(9775): 1438–1447.
- https://doi.org/10.1016/S0140-6736(11)60393-0
- Berman, A. & R. J. Plemmons, 1994. Nonnegative Matrices in the Mathematical Sciences. In Society
- for Industrial and Applied Mathematics.
- Bhunu, C. P. 2012. A mathematical Analysis of Alcoholism. World Journal of Modelling and Simulation,
- (2): 124–134.
- Bhunu, C. P., W. Garira & G. Magombedze. 2009. Mathematical Analysis of a Two Strain HIV/AIDS
- model With Antiretroviral Treatment. Acta Biotheoretica, 57(3), 361–381.
- Birkhoff, G. & G.-C. Rota. 1989. Ordinary Differential Equations (4th ed.). John Wiley and Sons.
- Bonyah, E., M. A. Khan, K. O. Okosun & J. F. Gómez-Aguilar. 2019. Modelling the Effects of Heavy
- Alcohol Consumption on the Transmission Dynamics of gonorrhea With Optimal Control.
- Mathematical Biosciences, 309(December 2018): 1–11. https://doi.org/10.1016/j.mbs.2018.12.015:
- Braithwaite, R. S., K. A Nucifora,., J. Kessler, C. Toohey, S. M. Mentor, L. M. Uhler, M. S. Roberts &
- K. Bryant, 2014. Impact of Interventions Targeting Unhealthy Alcohol Use in Kenya on HIV
- Transmission and AIDS-Related Deaths. Alcoholism: Clinical and Experimental Research, 38(4),
- –1067. https://doi.org/10.1111/acer.12332
- Castens, V., F. Luginga, B. Shayo & C. Tolias. 2012. Alcohol Abuse in Urban Moshi, Tanzania.
- Castillo-Chavez, C., Z. Feng & W. Huang. 2002. On the Computation of R 0 and its Role on Global
- Stability. 229–250. https://doi.org/10.1007/978-1-4757-3667-0_13
- Fleming, W. H. & R. W. Rishel. 2012. Deterministic and Stochastic Optimal Control (Vol. 1). Springer
- Science & Business Media.
- Jasinski, D. R. & J. E. Henningfield. 1989. Human Abuse Liability Assessment by Measurement of
- Subjective and Physiological Effects. Testing for Abuse Liability of Drugs in Humans, 73–100.
- Joint United Nations Programme on HIV/AIDS & WHO. 2006. AIDS Epidemic Update, December
- World Health Organization.
- Joshi, H. R., S. Lenhart, M. Y. Li & L. Wang. 2006. Optimal Control Methods Applied to Disease
- Models. Contemporary Mathematics, 410: 187–208.
- Lutambi, A. M., M. A. Penny, T. Smith & N. Chitnis. 2013. Mathematical Modelling of Mosquito
- Dispersal in a Heterogeneous Environment. Mathematical Biosciences, 241(2): 198–216.
- https://doi.org/10.1016/j.mbs.2012.11.013
- Maksimov, V. I. 2013. On an Algorithm for Dynamic Reconstruction of the Input. Differential
- Equations, 49(1), 88–100. https://doi.org/10.1134/S0012266113010096
- Mushayabasa, S. & C. P. Bhunu. 2011. Modelling the Effects of Heavy Alcohol Consumption on the
- Transmission Dynamics of Gonorrhea. Nonlinear Dynamics, 66(4): 695–706. https://doi.org/
- 1007/s11071-011-9942-4
- Nuraini, N., R. Irawan & E. S. Zulkifli. 2011. Mathematical Modeling of HIV/AIDS Transmission among
- Injecting Drug Users with Methadone Therapy. Asian Trans. Basic Appl. Sci, 1: 10–15.
- Pandrea, I., K. I. Happel, A. M. Amedee, G. J. Bagby & S. Nelson. 2010. Alcohol’s Role in HIV
- Transmission and Disease Progression. Alcohol Research & Health.
- Sharp, P. M. & B. H. Hahn. 2011. Origins of HIV and the AIDS Pandemic. Cold Spring Harbor
- Perspectives in Medicine, 1(1). https://doi.org/10.1101/cshperspect.a006841
- Steen, R., T. E. Wi, A. Kamali & F. Ndowa. 2009. Control of Sexually Transmitted Infections and
- Prevention of HIV Transmission: Mending a Fractured Paradigm. Bulletin of the World Health
- Organization, 87: 858–865.
- Thomas, G. & E. M. Lungu. 2009. The Influence of Heavy Alcohol Consumption on HIV Infection and
- Progression. Journal of Biological Systems, 17(04): 685–712.
- Van Den Driessche, P. & J. Watmough. 2002. Reproduction Numbers and Sub-threshold Endemic
- Equilibria for Compartmental Models of Disease Transmission. Mathematical Biosciences, 180(1–
- , 29–48. https://doi.org/10.1016/S0025-5564(02)00108-6.
References
Agusto, F. B. 2009. Application of Optimal Control to the Epidemiology of HIV-Malaria Co-infection.
Advances in Disease Epidemiology, 2012(81): 141–170.
Agusto, F. B. & K. O. Okosun. 2010. Optimal Seasonal Biocontrol for Eichhornia Crassipes. International
Journal of Biomathematics, 3(3): 383–397. https://doi.org/ 10.1142/ S1793 5245 10001021
Beaglehole, R., R. Bonita, R. Horton, C. Adams, G. Alleyne, P. Asaria, …, … J. Watt. 2011. Priority
Actions for the Non-communicable Disease Crisis. The Lancet, 377(9775): 1438–1447.
https://doi.org/10.1016/S0140-6736(11)60393-0
Berman, A. & R. J. Plemmons, 1994. Nonnegative Matrices in the Mathematical Sciences. In Society
for Industrial and Applied Mathematics.
Bhunu, C. P. 2012. A mathematical Analysis of Alcoholism. World Journal of Modelling and Simulation,
(2): 124–134.
Bhunu, C. P., W. Garira & G. Magombedze. 2009. Mathematical Analysis of a Two Strain HIV/AIDS
model With Antiretroviral Treatment. Acta Biotheoretica, 57(3), 361–381.
Birkhoff, G. & G.-C. Rota. 1989. Ordinary Differential Equations (4th ed.). John Wiley and Sons.
Bonyah, E., M. A. Khan, K. O. Okosun & J. F. Gómez-Aguilar. 2019. Modelling the Effects of Heavy
Alcohol Consumption on the Transmission Dynamics of gonorrhea With Optimal Control.
Mathematical Biosciences, 309(December 2018): 1–11. https://doi.org/10.1016/j.mbs.2018.12.015:
Braithwaite, R. S., K. A Nucifora,., J. Kessler, C. Toohey, S. M. Mentor, L. M. Uhler, M. S. Roberts &
K. Bryant, 2014. Impact of Interventions Targeting Unhealthy Alcohol Use in Kenya on HIV
Transmission and AIDS-Related Deaths. Alcoholism: Clinical and Experimental Research, 38(4),
–1067. https://doi.org/10.1111/acer.12332
Castens, V., F. Luginga, B. Shayo & C. Tolias. 2012. Alcohol Abuse in Urban Moshi, Tanzania.
Castillo-Chavez, C., Z. Feng & W. Huang. 2002. On the Computation of R 0 and its Role on Global
Stability. 229–250. https://doi.org/10.1007/978-1-4757-3667-0_13
Fleming, W. H. & R. W. Rishel. 2012. Deterministic and Stochastic Optimal Control (Vol. 1). Springer
Science & Business Media.
Jasinski, D. R. & J. E. Henningfield. 1989. Human Abuse Liability Assessment by Measurement of
Subjective and Physiological Effects. Testing for Abuse Liability of Drugs in Humans, 73–100.
Joint United Nations Programme on HIV/AIDS & WHO. 2006. AIDS Epidemic Update, December
World Health Organization.
Joshi, H. R., S. Lenhart, M. Y. Li & L. Wang. 2006. Optimal Control Methods Applied to Disease
Models. Contemporary Mathematics, 410: 187–208.
Lutambi, A. M., M. A. Penny, T. Smith & N. Chitnis. 2013. Mathematical Modelling of Mosquito
Dispersal in a Heterogeneous Environment. Mathematical Biosciences, 241(2): 198–216.
https://doi.org/10.1016/j.mbs.2012.11.013
Maksimov, V. I. 2013. On an Algorithm for Dynamic Reconstruction of the Input. Differential
Equations, 49(1), 88–100. https://doi.org/10.1134/S0012266113010096
Mushayabasa, S. & C. P. Bhunu. 2011. Modelling the Effects of Heavy Alcohol Consumption on the
Transmission Dynamics of Gonorrhea. Nonlinear Dynamics, 66(4): 695–706. https://doi.org/
1007/s11071-011-9942-4
Nuraini, N., R. Irawan & E. S. Zulkifli. 2011. Mathematical Modeling of HIV/AIDS Transmission among
Injecting Drug Users with Methadone Therapy. Asian Trans. Basic Appl. Sci, 1: 10–15.
Pandrea, I., K. I. Happel, A. M. Amedee, G. J. Bagby & S. Nelson. 2010. Alcohol’s Role in HIV
Transmission and Disease Progression. Alcohol Research & Health.
Sharp, P. M. & B. H. Hahn. 2011. Origins of HIV and the AIDS Pandemic. Cold Spring Harbor
Perspectives in Medicine, 1(1). https://doi.org/10.1101/cshperspect.a006841
Steen, R., T. E. Wi, A. Kamali & F. Ndowa. 2009. Control of Sexually Transmitted Infections and
Prevention of HIV Transmission: Mending a Fractured Paradigm. Bulletin of the World Health
Organization, 87: 858–865.
Thomas, G. & E. M. Lungu. 2009. The Influence of Heavy Alcohol Consumption on HIV Infection and
Progression. Journal of Biological Systems, 17(04): 685–712.
Van Den Driessche, P. & J. Watmough. 2002. Reproduction Numbers and Sub-threshold Endemic
Equilibria for Compartmental Models of Disease Transmission. Mathematical Biosciences, 180(1–